Testicular germ cell tumor genomics

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Giant Testicular Mixed Germ Cell Tumor

Objective: We report a case that we believe to be the largest example of a testicular mixed germ cell tumor with a clearly defined histology pattern. Clinical Presentation and Interventions: A 21-year-old patient consulted a urologist concerning a giant testicular mass. At the time of presentation the tumor measured 29 ! 20 ! 16 cm, with a weight of 4,850 g. Serum ·-fetoprotein was over 15,000 ...

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Isolated eyeball metastasis of non-seminomatous germ cell testicular tumor.

INTRODUCTION Testicular tumors most frequently metastasize to regional lymph nodes. Non-seminomatous tumor metastasis of testicle (NSGCTT) to the eyeball is rare. CASE REPORT We presented a 24-year old man, referred to the ophthalmologist due to acute pain and abrupt loss of sight in the left eye accompanied by its enlargement. Orbital and endocranial computerized tomography (CT) was carried ...

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Familial testicular germ cell tumor: no associated syndromic pattern identified

BACKGROUND Testicular germ cell tumor (TGCT) is the most common malignancy in young men. Familial clustering, epidemiologic evidence of increased risk with family or personal history, and the association of TGCT with genitourinary (GU) tract anomalies have suggested an underlying genetic predisposition. Linkage data have not identified a rare, highly-penetrant, single gene in familial TGCT (FTG...

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[Importance of microlithiasis in testicular germ cell tumor ultrasound].

INTRODUCTION Testicular microlithiasis (TM) is an infrequent finding in testicular ultrasound and its clinical importance has not been completely defined. We analyzed the ultrasounds of patients with testicular germ cell tumors in order to analyze the correlation between TM, histological findings and clinical variables. METHODS AND MATERIALS Fifty-seven patients with germ cell tumors and radi...

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Histopathology and Biology of Testicular Germ Cell Tumor

The versatile histopathology, clinical presentation, and biologic behavior of testicular neoplasms reflect the complex composition of the male gonad. Each component can develop different tumor types; thus, there are testicular germ cell tumor (TGT), sex cord/stromal tumor, miscellaneous tumors arising from rete testis or paratesticular structures, and tumors not specific to testicular parenchym...

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ژورنال

عنوان ژورنال: Current Opinion in Urology

سال: 2017

ISSN: 0963-0643

DOI: 10.1097/mou.0000000000000347